Custom Research Diets > Atherogenic Diets (Rats & Mice)

Atherogenic Diets (Rats & Mice)


General Information
Atherogenic diets can be as simple as adding cholesterol and/or cholate to a standard rodent feed, or using a purified diet, usually high in fat, with various levels of cholesterol and/or cholate. The type of atherogenic diet best for any given experiment is dependent upon the animal model, the desired endpoint, and the length of feeding.

"Western" Diet
TD.88137 is often referred to in the literature as the "Western" Diet. This is a purified diet with 21% anhydrous milkfat (butterfat), 34% sucrose, and a total of 0.2% cholesterol. The formula originated with researchers at Rockefeller University, and is widely used with ApoE deficient and other like models. There are a number of modifications of TD.88137 with varying levels of added cholesterol, and with customer supplied compounds. Contact technical services for more information about TD.88137, modifications, or possible control diets.

"Paigen" Diet
This diet originated in the lab of Dr. Beverly Paigen with the dilution of a very concentrated purified diet (containing 5% cholesterol and 2% sodium cholate; sometimes referred to as the Thomas-Hartroft diet) with a standard mouse breeder diet (PMI 5015); 1 part purified diet to 3 parts standard diet. The resulting diet has 1.25% cholesterol and 0.5% sodium cholate. The literature cites the use of this diet in C57Bl/6 mice and in genetically modified mice. TD.88051 and TD.90221 are Teklad product codes for this diet. TD.94059 is a modification without sodium cholate. There are also versions of this diet using other standard diets. Contact technical services for more information about these diets or modifications.

Standard diets with added cholesterol
We have numerous formulas on file with varying levels of cholesterol added to standard diets. TD.01383 is one such example. Contact technical services with your specific needs.

Atherogenic diets for species other than rats and mice
Rabbits, hamsters, and swine are models used to study cardiovascular disease. See Rabbit Diets or Other Species for information and formula examples.


Formula examples:
TD.88137 Adjusted Calories Diet (42% from fat) (“Western” Diet)
TD.88051 Cocoa Butter and Purina Mouse Chow Diet (“Paigen” Diet)
TD.90221 Cocoa Butter Diet with 75% Purina Mouse (5015) (“Paigen” Diet)
TD.94059 Purina 5015, Cocoa Butter, Cholesterol, etc. (excludes sodium cholate)
TD.02028 Atherogenic Rodent Diet (1.25% cholesterol and 0.5% Cholic Acid)
TD.01383 2018 + 2% Cholesterol (standard diet base)

 

 

 

 

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